Flu Season Vaccine Updates - 2024-2025

For the 2024-2025 flu season in the United States, all vaccines are expected to be trivalent. 

These trivalent vaccines are designed to protect against three specific influenza strains,

• A(H1N1) virus, 
• A(H3N2) virus, 
• B/Yamagata lineage virus, 
• B/Victoria virus.

Each of these four vaccine virus components are selected based on the following,

• Which flu viruses are making people sick prior to the upcoming flu season,
• The extent to which those viruses are spreading prior to the upcoming flu season,
• How well the previous season’s vaccines may protect against those flu viruses, and
• The ability of vaccine viruses to provide cross-protection against a range of related flu viruses of the same type or subtype/lineage.

All flu Vaccine for 2024 - 2025 will be trivalent (3 Components)

Difference Between Trivalent vs Quadrivalent

Information About trivalent influenza (flu) vaccine

Trivalent flu vaccines protect against three different influenza viruses. 

Trivalent flu vaccines in the United States will include vaccine viruses or viral proteins from,

• One influenza A(H1N1) virus, 
• One influenza A(H3N2) virus, and 
• One influenza B/Victoria lineage virus.

*** Trivalent will not include an influenza B/Yamagata lineage vaccine virus or viral protein component.

Difference between Quadrivalent and Trivalent Flu vaccines

• Quadrivalent flu vaccines include vaccine viruses or viral proteins from four viruses,  

Trivalent flu vaccines	Quadrivalent flu vaccines
One Influenza A(H1N1)	One Influenza A(H1N1)
One Influenza A(H3N2)	One Influenza A(H3N2)
One Influenza B/Victoria lineage	One Influenza B/Victoria lineage
-	One B/Yamagata lineage

Flu Season Vaccine CPT Codes & NDC#

CPT Code	Labeler Name	Vaccine Name	Mode of Supply/ML	Age Range	NDC #
90653	Seqirus	Fluad Trivalent Preservative Free	0.5 mL (single-dose syringe)	65 yrs & older	70461-0024-03
90656	Seqirus	Afluria Trivalent Preservative Free	0.5 mL (single-dose syringe)	3 yrs & older	33332-0024-03
90656	Sanofi Pasteur	Fluzone Trivalent Preservative Free	0.5 mL (single-dose syringe)	6 months & older	49281-0424-50
90656	GlaxoSmithKline	Fluvarix Trivalent Preservative Free	0.5 mL (single-dose syringe)	6 months & older	58160-0884-52
90656		FluLaval Trivalent Preservative Free	0.5 mL (single-dose syringe)	6 months & older	19515-0810-52
90657	Seqirus	Afluria Trivalent Pediatric Dose	5.0 mL multi-dose vial (0.25 mL dose)	6 to 35 months	33332-0124-10
90657	Sanofi Pasteur	Fluzone Trivalent Pediatric Dose	5.0 mL multi-dose vial (0.25 mL dose)	6 to 35 months	49281-0641-15
90658	Seqirus	Afluria Trivalent	5.0 mL multi-dose vial (0.5 mL dose)	3 years & older	33332-0124-10
90658	Sanofi Pasteur	Fluzone Trivalent	5.0 mL multi-dose vial (0.5 mL dose)	6 months & older	49281-0641-15
90660	MedImmune	FluMist Trivalent	0.2 mL (single-use nasal spray)	2 to 49 years	66019-0311-10
90661	Seqirus	Flucelvax Trivalent Preservative Free	0.5 mL (single-dose syringe)	6 months & older	70461-0654-03
90661		Flucelvax Trivalent	5.0 mL multi-dose vial (0.5 mL dose)	6 months & older	70461-0554-10
90662	Sanofi Pasteur	Fluzone High-Dose Trivalent Preservative Free	0.5 mL (single-dose syringe)	65 years & older	49281-0124-65
90673	Sanofi Pasteur	Flublok Trivalent Preservative Free	0.5 mL (single-dose syringe	18 years & older	49281-0724-10

Reference

• List of Flu Vaccines 
• For NDC Click Here