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Flu Season Vaccine Updates - 2024-2025

For the 2024-2025 flu season in the United States, all vaccines are expected to be trivalent. 

These trivalent vaccines are designed to protect against three specific influenza strains,

  • A(H1N1) virus, 
  • A(H3N2) virus, 
  • B/Yamagata lineage virus, 
  • B/Victoria virus.
Each of these four vaccine virus components are selected based on the following,
  • Which flu viruses are making people sick prior to the upcoming flu season,
  • The extent to which those viruses are spreading prior to the upcoming flu season,
  • How well the previous season’s vaccines may protect against those flu viruses, and
  • The ability of vaccine viruses to provide cross-protection against a range of related flu viruses of the same type or subtype/lineage.
All flu Vaccine for 2024 - 2025 will be trivalent (3 Components)

Difference Between Trivalent vs Quadrivalent


Information About trivalent influenza (flu) vaccine


Trivalent flu vaccines protect against three different influenza viruses. 
Trivalent flu vaccines in the United States will include vaccine viruses or viral proteins from,
  • One influenza A(H1N1) virus, 
  • One influenza A(H3N2) virus, and 
  • One influenza B/Victoria lineage virus.
*** Trivalent will not include an influenza B/Yamagata lineage vaccine virus or viral protein component.

Difference between Quadrivalent and Trivalent Flu vaccines


  • Quadrivalent flu vaccines include vaccine viruses or viral proteins from four viruses,  

Trivalent flu vaccines

Quadrivalent flu vaccines

One Influenza A(H1N1)

One Influenza A(H1N1)

One Influenza A(H3N2)

One Influenza A(H3N2)

One Influenza B/Victoria lineage

One Influenza B/Victoria lineage

-

One B/Yamagata lineage


Flu Season Vaccine CPT Codes & NDC#

CPT Code

Labeler Name

Vaccine Name

Mode of Supply/ML

Age Range

NDC #

90653

Seqirus

Fluad Trivalent Preservative Free

0.5 mL (single-dose syringe)

65 yrs & older

70461-0024-03

90656

Seqirus

Afluria Trivalent Preservative Free

0.5 mL (single-dose syringe)

3 yrs & older

33332-0024-03

90656 

Sanofi Pasteur

Fluzone Trivalent Preservative Free

0.5 mL (single-dose syringe)

6 months & older

49281-0424-50

 90656

GlaxoSmithKline

Fluvarix Trivalent Preservative Free

0.5 mL (single-dose syringe)

6 months & older

58160-0884-52

 90656

 

FluLaval Trivalent Preservative Free

0.5 mL (single-dose syringe)

6 months & older

19515-0810-52

90657

Seqirus

Afluria Trivalent Pediatric Dose

5.0 mL multi-dose vial (0.25 mL dose)

6 to 35 months

33332-0124-10

 90657

Sanofi Pasteur

Fluzone Trivalent Pediatric Dose

5.0 mL multi-dose vial (0.25 mL dose)

6 to 35 months

49281-0641-15

90658

Seqirus

Afluria Trivalent

5.0 mL multi-dose vial (0.5 mL dose)

3 years & older

33332-0124-10

 90658

Sanofi Pasteur

Fluzone Trivalent

5.0 mL multi-dose vial (0.5 mL dose)

6 months & older

49281-0641-15

90660

MedImmune

FluMist Trivalent

0.2 mL (single-use nasal spray)

2 to 49 years

66019-0311-10

90661

Seqirus

Flucelvax Trivalent Preservative Free

0.5 mL (single-dose syringe)

6 months & older

70461-0654-03

 90661

 

Flucelvax Trivalent

5.0 mL multi-dose vial (0.5 mL dose)

6 months & older

70461-0554-10

90662

Sanofi Pasteur

Fluzone High-Dose Trivalent Preservative Free

0.5 mL (single-dose syringe)

65 years & older

49281-0124-65

90673

Sanofi Pasteur

Flublok Trivalent Preservative Free

0.5 mL (single-dose syringe

18 years & older

49281-0724-10



Reference


ICD 10 CM Updates

Flu Season Vaccine Updates - 2024-2025

For the 2024-2025 flu season in the United States, all vaccines are expected to be trivalent.  These trivalent vaccines are designed to prot...